\\ obesity - a mental disease

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Alterations of the levels of long chain fatty acids in the hypothalamus are now shown to influence glucose homeostasis (pages 756­761).
>From the bench to the clinic, the past decade has been an exhilarating ride for diabetes and obesity researchers. Molecular mechanisms of insulin action have been identified and, since the discovery of leptin1, several brain circuits that control body weight have come to light. The pace of discovery shows no hint of slowing down. New findings continue to merge previously distinct neurobiological models of obesity and metabolic models in the liver, adipocytes and skeletal muscle.


In this issue2, Obici et al. continue this trend, adding long-chain fatty acids (LCFAs) to the growing list of metabolic signals with physiologically relevant actions in the hypothalamus. Their analysis suggests that in addition to regulating food intake and body weight, hypothalamic circuits also regulate insulin action, providing insight into potential links between type 2 diabetes and obesity.